Top 5 Japanese Companies To Own For 2014

Japanese shares fell, with the Topix (TPX) index dropping for the first time in three days, as the yen held gains against the dollar after disappointing U.S. jobs data. Insurers led losses among the gauge�� 33 industry groups.

Insurance companies dropped 2.9 percent after jumping 8 percent in the last two days. T&D Holdings Inc. led the sector�� decline. Hitachi Zosen Corp. (7004) tumbled 5.7 percent after the environmental-equipment maker�� loss widened. Mitsumi Electric (6767) Co., which produces computer parts, slumped the most on the Nikkei 225 Stock Average after posting a 1.7 billion yen ($17.1 million) first-quarter loss. Casio Computer Co. jumped 5 percent after reporting a 31 percent increase in profit.

The Topix lost 1 percent to 1,184.74 at the close in Tokyo, with all but two subsectors falling. The gauge added 5.7 percent in the past two sessions, the biggest two-day advance since June 28. The Nikkei 225 fell 1.4 percent to 14,258.04. The yen traded at 98.61 per dollar from as much as 99.95 on Aug. 2.

Top Healthcare Technology Companies To Own In Right Now: Five Prime Therapeutics Inc (FPRX)

Five Prime Therapeutics, Inc., incorporated on December 20, 2001, is a clinical-stage biotechnology company focused on discovering and developing protein therapeutics. Protein therapeutics is antibodies or drugs developed from extracellular proteins or protein fragments that block disease processes, including cancer and inflammatory diseases. The Company�� advanced product candidates include FP-1039/GSK3052230 (FP-1039), FPA008 and FPA144. FP-1039 is a protein therapeutic that traps and neutralizes cancer-promoting fibroblast growth factors (FGFs), involved in cancer cell proliferation and new blood vessel formation. FPA008 is an antibody that inhibits colony stimulating factor-1 receptor (CSF1R), and is being developed to treat patients with inflammatory diseases, including rheumatoid arthritis (RA). FPA144 is an antibody that inhibits FGF receptor 2b (FGFR2b), and is being developed to treat patients with gastric cancer and potentially other solid tumors.

FP-1039

FP-1039 is a protein therapeutic, which includes the extracellular part of FGFR1. FP-1039 acts as an inhibitor of FGFs, because the FGFR1 portion of the molecule binds to FGFs and prevents them from binding to FGFR1 on tumor and blood vessel cells. Because FGF proteins circulating in the blood are called ligands, FP-1039 is called a ligand trap. FP-1039 also includes a portion of an antibody called the Fc region. In preclinical testing, it observed inhibition of tumor growth with single-agent FP-1039, particularly in tumors withFGFR1 gene amplification, including squamous NSCLC and SCLC.

FPA008

FPA008 is an antibody that inhibits CSF1R and is being developed to treat patients with RA. FPA008 also has the potential to treat patients with other inflammatory diseases, including lupus nephritis, psoriatic arthritis, ankylosing spondylitis, fibrosis, inflammatory bowel disease and multiple sclerosis. These are chronic, incurable disorders with serious medical complications and disability for ! which better therapies with novel mechanisms of action are needed. FPA008 is an anti-CSF1R antibody, which it designed to block the ability of IL-34 and CSF1 to bind to and activate CSF1R. FPA008 reduces the numbers and activity of monocytes and macrophages that cause disease, and prevents the production and release of inflammatory factors. The Company and others has demonstrated that both IL-34 and CSF1 are present at increased levels in the inflamed joints of patients with RA.

FPA144

FPA144 is a monoclonal antibody directed against a form of FGFR2, or FGFR2b. When the FGFR2 gene is amplified by cancer cells, the FGFR2b protein is expressed at abnormally high levels on the tumor�� surface. This occurs in some patients with gastric and lower esophageal cancers. The tumor cells that have too much FGFR2b protein on their surface can be identified by special staining tests performed on the tumor. Because FGFR2b is the target for FPA144, patients��tumors can be screened for this protein, helping to identify the patients most likely to respond to FPA144 treatment.

Advisors' Opinion:

• [By Monica Gerson]

  Breaking news

  Alcoa (NYSE: AA) is investing US$13 million to expand its wheel manufacturing plant in Europe, to meet growing demand for its lightweight, durable, low-maintenance aluminum truck wheels. To read the full news, click here. L & L Energy (NASDAQ: LLEN) announced today that its Special Independent Committee has appointed Mr. Nicholas Chen, Managing Partner at Pamir Law Group, to replace Mr. Mark Bartlett. To read the full news, click here. Five Prime Therapeutics (NASDAQ: FPRX) and Bristol-Myers Squibb (NYSE: BMY) announced today that they have signed a collaboration agreement for the discovery, development and commercialization of immuno-oncology therapies directed toward targets identified in two undisclosed immune checkpoint pathways using Five Prime's proprietary target discovery platform. To read the full news, click here. First Solar (NASDAQ: FSLR) on Sunday announced the completion of the 1.3MW(DC) solar photovoltaic (PV) power plant at Kitakyushu-shi. Powered by First Solar FS Series 3 Black PV modules, the plant will generate approximately 1,400 MWh of clean and safe solar electricity per year. To read the full news, click here.

  Posted-In: Credit Suisse US Stock FuturesNews Eurozone Futures Global Pre-Market Outlook Markets

• [By John Kell and Tess Stynes var popups = dojo.query(".socialByline .popC"); p]

  Among the companies with shares expected to actively trade in Monday’s session are Keurig Green Mountain Inc.(GMCR), JA Solar Holdings Co.(JASO) and Five Prime Therapeutics Inc.(FPRX)

Top 5 Japanese Companies To Own For 2014: Vanda Pharmaceuticals Inc.(VNDA)

Vanda Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of products for the treatment of central nervous system disorders. Its lead product includes Fanapt for the acute treatment of schizophrenia in adults. The company is also developing Tasimelteon, an orphan medicinal product for the treatment of sleep and mood disorders, including non-24 hour sleep/wake disorder in blind individuals without light perception. It also intends to initiate a Phase IIb/III clinical trial of tasimelteon in patients with major depressive disorder; and conduct additional clinical trials to support the use of tasimelteon as a circadian regulator. The company was incorporated in 2002 and is headquartered in Rockville, Maryland.

Advisors' Opinion:

• [By Paul Ausick]

  Stocks on the Move: Vanda Pharmaceuticals Inc. (NASDAQ: VNDA) is up 95.8% at $13.29 on FDA recommendation for approval of its sleep drug for the blind. Sarepta Therapeutics Inc. (NASDAQ: SRPT) is down 64.3% at $13.05 following an FDA rejection of the company�� bid to fast-track muscular dystrophy drug. U.S. Airways Group Inc. (NYSE: LCC) is up 1.1% at $23.53 after reaching an agreement with the Department of Justice that will let the company go ahead with its American Airlines merger.

• [By Nathalie Tadena]

  Among the companies with shares expected to actively trade in Friday’s session are Vanda Pharmaceuticals Inc.(VNDA), Kimberly-Clark(KMB) and Cell Therapeutics(CTIC).

• [By Ben Levisohn]

  It was the night before the ECB–and two before US payrolls–and all through the market nothing was stirring, not even…Alright. Some things were stirring, like the shares of Protective Life (PL), Travelers Companies (TRV), Under Armour (UA), Broadcom (BRCM) and Vanda Pharmaceuticals (VNDA).

Top 5 Japanese Companies To Own For 2014: Level 3 Communications Inc.(LVLT)

Level 3 Communications, Inc. engages in the communications business in North America and Europe. It offers network and Internet services, including transport services, high speed Internet protocol services, dedicated Internet access, virtual private network services, and dark fiber services, as well as managed modem, an outsourced, turn-key infrastructure solution; and colocation services. The company also provides various media services, comprising Vyvx services that provide audio and video feeds over fiber or satellite; content delivery network services; media delivery services to customers seeking to manage, protect, and monetize content delivered over the Internet; a range of local and long distance voice services, such as voice over Internet protocol (VoIP) and traditional circuit-switch based services; and VoIP Enhanced Local, a VoIP service that enables broadband cable operators, IXCs, VoIP providers, and other companies operating their own switching infrastructure to launch IP-based local and long-distance voice services through a broadband connection. Level 3 Communications? media services also consist of SIP Trunking, a VoIP-based local phone service; Local Inbound service that terminates traditional telephone network originated calls to Internet Protocol termination points; Primary Rate Interface, a TDM local phone service that could be configured in various ways; Long Distance services portfolio comprising local and long distance transport and termination services; and Toll Free services portfolio, which terminate toll free calls that are originated on the traditional telephone network. As of December 31, 2010, its network encompassed approximately 68,000 intercity route miles in North America and an intercity network covering approximately 13,000 miles across Europe. Further, it sells coal primarily through long-term contracts with public utilities. The company was founded in 1884 and is headquartered in Broomfield, Colorado.

Advisors' Opinion:

• [By Lee Jackson]

  Level 3 Communications Inc. (NYSE: LVLT) is a Fortune 500 company that provides local, national and global communications services to enterprise, government and carrier customers. Level 3′s comprehensive portfolio of secure, managed solutions includes fiber and infrastructure solutions, IP-based voice and data communications, wide-area Ethernet services, video and content distribution, as well as data center and cloud-based solutions. The consensus price target for the stock is $25.75. Level 3 closed at $27.94.

• [By Rich Smith]

  Just one month after alerting investors to the possibility, Broomfield, Colorado-based Level 3 Communications (NYSE: LVLT  ) is under new management today. The global voice and data carrier announced Thursday that company President and Chief Operating Officer Jeff K. Storey has been promoted to Chief Executive Officer, replacing outgoing CEO James Q. Crowe.

Top 5 Japanese Companies To Own For 2014: DC Brands International Inc (HRDN)

DC Brands International, Inc. (DC Brands), incorporated on April 29, 1998, is engaged in the manufacture, marketing and distribution of health-related products that utilize natural botanicals, vitamins, minerals and supplements. As of December 31, 2009, the Company focused on the sale of products under its H.A.R.D. Nutrition label. As of December 31, 2009, the Company had two distinct types of products sold under its H.A.R.D. Nutrition logo, such as Functional Water Systems and nutritional supplements. Its H.A.R.D. Nutrition Functional Water System provides consumers with the combination of nutraceutical supplements with a functional beverage. All of the products sold under its H.A.R.D. Nutrition Functional Water System are sold in a bottle, which combines in one container water, which is lightly flavored, with vitamins stored in its licensed flip top compartment on the top of the bottle. DC Brands also sells other products included in its H.A.R.D. Nutrition label, such as herbal supplements, which are made from a mixture of herbs. The Company�� products are sold to consumers, primarily through retail outlet distribution. The Company�� wholly owned subsidiaries are DC Nutrition, Inc. and DC Brands, LLC. As of December 31, 2009, DC Brands, LLC was inactive. In June 2013, DC Brands International Inc acquired an undisclosed minority stake in Village Tea Co Distribution Inc.

Functional Water Systems

DC Brands��Functional Water Systems are a combination of a functional beverage and a nutraceutical. The Company provides consumers with a combination of a beverage and a nutraceutical supplement all in one convenient bottle. As of December 31, 2009, the Company manufactured nine water systems. Each system includes supplements, vitamins and minerals that are enclosed in its licensed cap, which is attached to its bottle filled with a lightly flavored water specially formulated to act as a catalyst for the enclosed supplements. The Functional Water Systems have a shelf life of one! year. The Company conducts periodic tests of the color, flavor and desired results of its products in house. Each product contains a label with a date stamp that specifies the shelf life.

The Company�� nine different systems are The Daily Basics, The Fat Fighter, The Get Over It-Feel Better Now, Whacked Energy, Wide Awake, Win, Fix It, Cleanse +, and Rebuild and Recover. The Daily Basics is a wellness product that includes vitamins and supplements. The Fat Fighter falls under the diet and weight loss category. The Get Over It-Feel Better Now is a wellness product that is a blend of vitamins, herbs and minerals. As of December 31, 2009, The Get Over It-Feel Better Now water system was sold in certain hotels in Las Vegas on a trial basis and was stocked in the guest rooms in the hotels and was marketed to combat hangovers. Whacked Energy and Wide Awake are part of its energy line. Win is geared towards athletes for use when conducting fitness training. Fix It is a combination of herbs and supplements. Cleanse+ is a 12 days total body cleansing system intended to be taken once every 90 days and Rebuild and Recover is a combination of products focused towards the serious athlete. All of its products contain ingredients that are focused to provide health-related benefits. The H.A.R.D. Nutrition Functional Water Systems are primarily sold in retail establishments.

Nutritional Supplements

The Company�� H.A.R.D. Nutrition Supplements are sold primarily though its wholly owned subsidiary DC Nutrition, Inc. and are focused at athletes and improving performance. As of December 31, 2009, the Company had approximately 300 products in this product line, which it divided into the four categories: performance and strength supplements, wellness products, energy supplements, and the weight loss and diet products.

The Company competes with Coca-Cola and Pepsi.

Advisors' Opinion:

• [By Peter Graham]

  Small cap stocks COREwafer Industries Inc (OTCMKTS: WAFR), DC Brands International, Inc (OTCMKTS: HRDN) and PV Enterprises International (OTCMKTS: PVEC) surged 82.86%, 33.33% and 25%, respectively, last Friday ��meaning investors or traders got a nice Christmas present. Moreover, these small cap stocks have been the subject of minimal paid stock promotions. But will these three small cap stocks continue to deliver a good performance into and after the holidays? Here is a quick reality check before you get overly excited: